First-line methadone for cancer pain: titration time analysis

Methadone is a low-cost, strong opioid that is increasingly used as a first-line treatment for pain in palliative care (PC). Its long and unpredictable half-life and slow elimination phase can make titration challenging. Evidence for titration modalities is scarce.

https://link.springer.com/article/10.1007/s00520-021-06211-y