The Abscopal Effect in the Era of Checkpoint Inhibitors

Int J Mol Sci. 2021 Jul 4;22(13):7204. doi: 10.3390/ijms22137204.ABSTRACTTherapy targeting immune checkpoints represents an integral part of the treatment for patients suffering from advanced melanoma. However, the mechanisms of resistance are responsible for a lower therapeutic outcome than expected. Concerning melanoma, insufficient stimulation of the immune system by tumour neoantigens is a likely explanation. As shown previously, radiotherapy is a known option for increasing the production of tumour neoantigens and their release into the microenvironment. Consequently, neoantigens could be recognized by antigen presenting cells (APCs) and subjected to effector T lymphocytes. Enhancing the immune reaction can trigger the therapeutic response…
Origen: The Abscopal Effect in the Era of Checkpoint Inhibitors – PubMed

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