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The enigma of multicentric glioblastoma: physiopathogenic hypothesis and discussion about two cases.

Related Articles The enigma of multicentric glioblastoma: physiopathogenic hypothesis and discussion about two cases. Br J Neurosurg. 2018 Dec;32(6):610-613 Authors: Picart T, Le Corre M, Chan-Seng E, Cochereau J, Duffau H Abstract Two men were admitted following generalized seizures. Cerebral MRI-scans showed multiple independent enhancing lesions which were bilateral (first case) and unilateral but disseminated to the brainstem (second case). Whole-body CT-scans showed no primaries. Both cases were diagnosed by biopsy as IDH1 wild-type multicentric glioblastoma. Treatment of both was palliative. The natural history of this entity remains matter of debate but 2 genomic analysis strikingly revealed that foci from…
Origen: The enigma of multicentric glioblastoma: physiopathogenic hypothesis and discussion about two cases. – PubMed

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