Related Articles Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity. Support Care Cancer. 2020 Dec;28(12):6145-6157 Authors: Shannon VR, Anderson R, Blidner A, Choi J, Cooksley T, Dougan M, Glezerman I, Ginex P, Girotra M, Gupta D, Johnson DB, Suarez-Almazor ME, Rapoport BL Abstract The immune checkpoints associated with the CTLA-4 and PD-1 pathways are critical modulators of immune activation. These pathways dampen the immune response by providing brakes on activated T cells, thereby ensuring more uniform and controlled immune reactions and avoiding immune hyper-responsiveness and autoimmunity. Cancer…
Origen: Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity. – PubMed

Healthc Q. 2021 Jan;23(4):17-22. doi: 10.12927/hcq.2020.26398.ABSTRACTPatients with serious illnesses such as cancer, advanced organ failure, dementia and COVID-19 rely on medications to alleviate suffering from uncontrolled symptoms. Numerous actual or threatened shortages of key medications used to provide palliation have been reported during the COVID-19 pandemic. This article explores the nature of these shortages, factors that have contributed to them and strategies to mitigate them. It calls on all levels of the healthcare system and the government to address this problem. Shortages in these medications are as serious as shortages in medications used to cure or control diseases.PMID:33475487 | DOI:10.12927/hcq.2020.26398
Origen: Shortages of Palliative Care Medications in Canada during the COVID-19 Pandemic: Gambling with Suffering – PubMed

Gan To Kagaku Ryoho. 2020 Dec;47(13):2177-2179.ABSTRACTMalignant esophageal stenosis adversely affects the quality of life(QOL)on account of poor oral intake. Endoscopic esophageal stenting is one of palliative therapy for improve QOL because of minimally invasive and simple procedure. We investigated the outcomes of esophageal stenting in our institution. Twenty patients with malignant esophageal stenosis who underwent esophageal stenting in our institution between April 2014 and December 2019 were included in this study. Six(30%)out of 20 patients showed fistula. Dysphagia score was improved significantly before and after stenting(3.3± 0.6 vs 1.8±0.9, p<0.01). Complications associated with stenting occurred in 6(30%)cases. Thirteen(65%)patients were able…
Origen: The Efficacy of Endoscopic Esophageal Stent Placement for Malignant Esophageal Stenosis – PubMed

Gan To Kagaku Ryoho. 2020 Dec;47(13):2364-2366.ABSTRACTCase 1: The patient was a 74-year-old man with a performance status(PS)of 0. He was referred to our department for pyloric gastric cancer with multiple liver, lung, and lymph node metastases. We started chemotherapy after making the diagnosis of an unresectable gastric cancer. During chemotherapy, the hemoglobin level dropped due to bleeding from the tumor. We attempted endoscopic hemostasis, which was not successful; therefore, we attempted a palliative radiotherapy. The total dose was 30 Gy in 10 Fr and hemostasis was achieved on the 10th day from the start of the radiotherapy. There were no…
Origen: Two Cases of Unresectable Gastric Cancer Where Bleeding Was Controlled by Radiation – PubMed

Rev Med Suisse. 2021 Jan 20;17(722):147-149.ABSTRACTThe death of a patient taking opioids can generate strong feelings of guilt. « Have I hastened my patient’s death by my administration of opioids ? » Doubts may arise in certain situations, despite the proven safety of appropriate opioid use in the management of dyspnea and pain in the palliative care setting. Fearing the harms of opioid administration, some medical practitioners may undertreat patients, forsaking them to suffering. Other doctors, desperate to relieve their excruciating suffering at all cost, may in fact have recourse to euthanizing acts. This article seeks to answer this ethical…
Origen: Extreme end-of-life situations and opioids : the double effect principle, a helpful guide – PubMed